Axofreeze -150 °C Ultra-Low Temperature Chest Freezer MF-150H239, 239 l, capacity 15,000 samples
item number: 40816
Capacity 150 boxes with 50 mm height
List price € 26.900,00
Ultra-low temperature chest freezers -86°C to -150°C -150°C ultra-low temperature freezers
-150°C ultra-low temperature chest freezers enable true cryopreservation without the need for liquid nitrogen. Below -130°C, water adopts a glass-like structure, causing all biological and chemical processes to cease completely. The range includes models from 118 to 258 litres with capacities ranging from 4,800 to 16,500 sample tubes.
Ultra-low temperature chest freezers -86°C to -150°C / -150°C ultra-low temperature freezers
-150°C Freezer INNOVA MF-150H258P, 258 l, Capacity 16,500 Samples
item number: 40502
Capacity 165 boxes with 50 mm height
List price € 24.880,00
-150°C Freezer INNOVA MF-150H118P, 118 l, Capacity 4800 Samples
item number: 40501
Capacity 48 boxes with 50 mm height
List price € 16.239,00
-150°C Ultra-Low Temperature Chest Freezers: Cryopreservation vs. -86°C
The critical physical difference between -86°C and -150°C storage lies in the state of water: below approximately -130°C, water transitions into a glass-like (amorphous) state. Enzymatic reactions, oxidation processes, and crystal formation come to a complete standstill. At -86°C, these processes are significantly slowed but not fully halted—for storage over decades or for particularly sensitive cell materials, this temperature difference can be decisive.
Technical specifications of available models
The range includes three models: Innova MF-150H118P (118 l, 48 cryoboxes, 4,800 samples), Innova MF-150H258P (258 l, 165 cryoboxes, 16,500 samples), and Axofreeze MF-150H239 (239 l, 150 cryoboxes, 15,000 samples). All specifications apply to cryoboxes with a height of 50 mm. All units operate with mechanical cascade cooling and do not require liquid nitrogen—eliminating the logistics of refilling, evaporation losses, and the specific safety requirements associated with handling cryogens.
Typical areas of application
-150°C cryo-freezers are used for the long-term preservation of stem cells and induced pluripotent stem cells (iPSC), cell lines for CAR-T and other cell therapy programmes, germ cells and embryos in reproductive medicine, and for biobanks with a long-term horizon of over 10 years. For GMP-regulated applications, qualification (IQ/OQ/PQ) and connection to a continuous temperature monitoring system are recommended.
Frequently asked questions about -150°C ultra-low temperature chest freezers
Why -150°C instead of -86°C, which capacities are available, and what are the advantages of mechanical cooling over liquid nitrogen—an overview of the most important questions regarding -150°C cryo-freezers.
Why -150°C instead of -86°C for cryopreservation?
Below -130°C, water adopts a glass-like (amorphous) structure—enzymatic reactions, oxidation processes, and ice crystal formation come to a complete standstill. At -86°C, these processes are significantly slowed but not fully stopped. For stem cells, iPSC lines, cells for cell therapy programmes, and long-term storage over decades, -150°C is the safer choice.
What is the advantage over liquid nitrogen?
-150°C cryo-freezers with mechanical cascade cooling do not require liquid nitrogen. This eliminates refilling logistics, evaporation losses, special safety requirements for handling cryogens, and dependence on nitrogen supply. Operation is possible with a standard power connection.
Which capacities are available?
The range includes three models: Innova MF-150H118P (118 l, 48 cryoboxes, approx. 4,800 samples), Innova MF-150H258P (258 l, 165 cryoboxes, approx. 16,500 samples), and Axofreeze MF-150H239 (239 l, 150 cryoboxes, approx. 15,000 samples). All specifications apply to cryoboxes with a height of 50 mm.
For which applications are -150°C cryo-freezers suitable?
Typical applications include the long-term preservation of stem cells and iPSC lines, cell lines for CAR-T and other cell therapy programmes, germ cells and embryos in reproductive medicine, and biobanks with a long-term horizon. In GMP environments, qualification (IQ/OQ/PQ) is required.
How are -150°C cryo-freezers monitored?
For seamless temperature documentation, an external WLAN data logger with alarm forwarding is recommended, which alerts via email or SMS if limits are exceeded. In GMP environments, continuous recording is a prerequisite for regulatory compliance.